Search results for "Carbapenem resistance"

showing 5 items of 5 documents

Rapid detection of carbapenem resistance: Targeting a zero level of inadequate empiric antibiotic exposure

2016

Resistance to carbapenems is an increasingly encountered phenomenon in the ICU, complicating empiric and targeted antimicrobial therapy. Infections due to carbapenem-resistant microorganisms are characterized by high morbidity and mortality [1, 2]. Recently, there has been an increasing interest in rapid detection techniques, based on real time on-demand easy-to-use PCR, to detect genes responsible for carbapenem resistance. One of these techniques is the Cepheid Xpert Carba-R assay, which is able to detect and differentiate five of the most frequent genes associated with non-susceptibility to carbapenems in Gram-negative bacteria (bla KPC, bla VIM, bla OXA-48, bla IMP-1, bla NDM). The diag…

0301 basic medicineGram-negative bacteriaLetterCarbapenem resistanceMultidrug-resistant bacteria030106 microbiologyDrug ResistanceDrug resistanceCritical Care and Intensive Care MedicineMicrobiologylaw.invention03 medical and health sciences0302 clinical medicinelawGram-Negative Bacteriapolycyclic compoundsMedicineInfection controlHumansCarbapenem resistance; Multidrug-resistant bacteria; Polymerase chain reaction; Critical Care and Intensive Care MedicinePolymerase chain reactionCarbapenem resistancebiologybusiness.industryOutbreak030208 emergency & critical care medicinebiochemical phenomena metabolism and nutritionbacterial infections and mycosesbiology.organism_classificationAntimicrobialPolymerase chain reactionIntensive Care UnitsCarbapenemsEtiologyCarbapenem resistance; Multidrug-resistant bacteria; Polymerase chain reactionbusiness
researchProduct

Outbreak of ST395 KPC-Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit in Palermo, Italy

2018

0301 basic medicineMicrobiology (medical)Klebsiella pneumoniae Neonatal Intensive Care Unit Carbapenem resistance KPC Outbreakmedicine.medical_specialtyNeonatal intensive care unitEpidemiologyKlebsiella pneumoniae030106 microbiologySettore MED/42 - Igiene Generale E Applicatabeta-Lactam ResistanceDisease Outbreaks03 medical and health sciencesIntensive Care Units NeonatalmedicineHumansBacteriological TechniquesInfection ControlbiologyOutbreakbiology.organism_classificationKlebsiella InfectionsKlebsiella pneumoniae030104 developmental biologyInfectious DiseasesCarbapenemsItalyEmergency medicineBeta lactam antibiotics
researchProduct

Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients

2013

Objectives: This investigation was conducted to study co-colonization by carbapenem-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) and Acinetobacter baumannii (CRAB) in intensive care unit (ICU) patients in Palermo, Sicily, a geographic area where both organisms are endemic in the healthcare setting. Risk factors at admission and during ICU stay and outcomes were also evaluated. Methods: All patients colonized by KPC-Kp, or CRAB, or both in 2 ICUs of a large general hospital during the period October 2011 – March 2012 were enrolled. Demographics and clinical data were collected. Resistance determinants and clonality of the 2 organisms were characterized by mo…

Acinetobacter baumanniiAdultMaleMicrobiology (medical)medicine.medical_specialtyPediatricsYounger ageGenotypeCarbapenem resistant Klebsiella pneumoniaeKlebsiella pneumoniaeCritical IllnessSettore MED/42 - Igiene Generale E ApplicataHospitals Generalbeta-Lactamaseslaw.inventionBacterial ProteinsRisk FactorslawInternal medicineDrug Resistance BacterialmedicineHumansGeneral hospitalSicilyAgedAged 80 and overGeneral Immunology and MicrobiologybiologyCoinfectionbusiness.industryMajor traumaGeneral MedicineMiddle Agedbiology.organism_classificationmedicine.diseaseIntensive care unitCarbapenem resistance co-colonization intensive care unit risk factorsKlebsiella InfectionsAcinetobacter baumanniiMolecular TypingIntensive Care UnitsKlebsiella pneumoniaeInfectious DiseasesFemaleCo colonizationbusinessAcinetobacter InfectionsScandinavian Journal of Infectious Diseases
researchProduct

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials…

2019

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9…

Infection riskMaleBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences.Antibiotic resistanceTracte gastrointestinal - MalaltiesDefinitionsCritical Care and Intensive Care MedicineTHERAPYDEFINITIONS:Infections::Intraabdominal Infections [DISEASES]0302 clinical medicineIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; Sepsis;[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesObservational studySeptic shockIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; SepsisComputingMilieux_MISCELLANEOUSCritical Illness/epidemiology[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti.Intraabdominal Infections/epidemiologyAbdominal infectionMulticenter study3. Good healthManagementClinical trialCohort[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCohort analysisCommunity acquired infectionCohort studyHumanmedicine.medical_specialtyCarbapenem resistanceCritical IllnessPeritoneal dialysisPeritonitisVancomycin resistant enterococcusMajor clinical studyPeritonitisArticle03 medical and health sciencesAntibiotic resistance[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemIntensive careSepsisSettore MED/41 - ANESTESIOLOGIAHumansCritical care medicineHospital infectionAgedScience & TechnologyLiver failureAntibiotic therapymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyEpidemiologic Studies030228 respiratory systemIntensive Care Unit; Sepsis (Diptera); Septic ShockRisk factorHuman medicineGeneral & internal medicineCongestive heart failureOriginalMultidrug resistanceCohort StudiesRisk FactorsCause of DeathEpidemiologyPrevalenceMedicine and Health SciencesAbdominal abscessSepsis/epidemiologyMiddle agedAntifungal therapy2. Zero hungerPeritonitiAntibiotic agentBiliary tract infectionIntensive care ; Intra-abdominal infection ; Mortality ; Multidrug resistance ; Peritonitis ; SepsisMiddle Aged:infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES]PREVALENCE:Infections::Sepsis [DISEASES]:técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Methicillin resistant staphylococcus aureusRaonament basat en casosFemaleCritically ill patientLife Sciences & BiomedicineAntifungal agentAdult:Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Predictive value:infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES]NOSepsisIntra-abdominal infectionCritical Care MedicineInternal medicineGeneral & Internal MedicinemedicineMANAGEMENTJournal Article[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologySepticèmiaMortalitybusiness.industrySeptic shockPancreas diseaseMalnutrition030208 emergency & critical care medicineTyphlitisToxic megacolonIntensive careIntraabdominal InfectionsTherapyLate onset disorderbusiness
researchProduct

NDM-1 and OXA-163 producing Klebsiella pneumoniae isolates in Cairo, Egypt, 2012

2013

Here we describe carbapenem resistance determinants in two Klebsiella pneumoniae isolates recovered from two hospitalised patients in the same intensive care unit of a cancer hospital in Cairo, Egypt. PCR and sequencing were used to detect and characterise β-lactamase genes. Clonal relationships between the isolates were analysed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). The first K. pneumoniae isolate carried the blaNDM-1 gene and the second isolate carried the blaOXA-163 gene. Both isolates co-expressed the extended-spectrum β-lactamase CTX-M-15. The two isolates belonged to different sequence types (STs), ST11 and ST16, respectively. No history of …

Microbiology (medical)Antimicrobial drug resistanceSettore MED/07 - Microbiologia E Microbiologia ClinicaOXA-163biologyGeographic areaKlebsiella pneumoniaeImmunologyNorth africaSequence typesNDM-1biology.organism_classificationMicrobiologyVirologyMicrobiologyCarbapenemaseKlebsiella pneumoniaeNDM-1; OXA-163; Carbapenemase; Klebsiella pneumoniae; Antimicrobial drug resistancePulsed-field gel electrophoresisImmunology and AllergyMultilocus sequence typingCarbapenem resistance
researchProduct